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Term Information

Accession
GO:0140536
Name
nuclear receptor corepressor activity
Ontology
molecular_function
Synonyms
nuclear corepressor activity
Alternate IDs
None
Definition
A transcription corepressor activity that represses or decreases the transcription of specific gene sets via binding to a DNA-bound nuclear receptor, either on its own or as part of a complex. Nuclear receptor corepressors often act by altering chromatin structure and modifications. For example, one class of transcription nuclear receptor corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. Source: PMID:7566126, PMID:7566114, PMID:9238851
Comment
For usage guidance, see comment in GO:0003712 ; transcription coregulator activity.
History
See term history for GO:0140536 at QuickGO
Subset
None
Feedback
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Parents of nuclear receptor corepressor activity (GO:0140536)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
nuclear receptor corepressor activity [BFO:0000050 relation] BFO:0000050  negative regulation of transcription by RNA polymerase II (GO:0000122)
nuclear receptor corepressor activity [is_a relation] is_a  transcription corepressor activity (GO:0003714)

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None.