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Term Information

Accession
GO:0003712
Name
transcription coregulator activity
Ontology
molecular_function
Synonyms
transcription cofactor activity, transcriptional co-regulator, RNA polymerase II transcriptional cofactor activity
Alternate IDs
GO:0001104, GO:0016455
Definition
A transcription regulator activity that modulates the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. Source: GOC:txnOH-2018, PMID:10213677, PMID:16858867, Wikipedia:Transcription_coregulator, PMID:24203923, PMID:25957681
Comment
Usage guidance: Most transcription coregulators do not bind DNA. Those that do usually bind DNA either in a non-specific or non-direct manner. If a protein binds DNA specifically, consider annotating to GO:0003700 DNA binding transcription factor activity.
History
See term history for GO:0003712 at QuickGO
Subset
goslim_drosophila
Feedback
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Parents of transcription coregulator activity (GO:0003712)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
transcription coregulator activity [is_a relation] is_a  transcription regulator activity (GO:0140110)
Children of transcription coregulator activity (GO:0003712)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
transcription corepressor activity (GO:0003714) [is_a relation] is_a  transcription coregulator activity
transcription coactivator activity (GO:0003713) [is_a relation] is_a  transcription coregulator activity
None.