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extrinsic apoptotic signaling pathway
Term Information
Accession
GO:0097191
Name
extrinsic apoptotic signaling pathway
Ontology
biological_process
Synonyms
extrinsic apoptotic pathway, extrinsic apoptotic signalling pathway, death receptor-mediated apoptosis, extrinsic apoptosis, extrinsic apoptotic signaling pathway in presence of ligand
Alternate IDs
None
Definition
The series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with either a ligand binding to a cell surface receptor, or a ligand being withdrawn from a cell surface receptor (e.g. in the case of signaling by dependence receptors), and ends when the execution phase of apoptosis is triggered.
Source:
GOC:yaf,
GOC:mtg_apoptosis,
PMID:17340152
Comment
Fas acts as a death receptor with a role in apoptosis, but can also act as a non-apoptotic signal transducer.
Link
to all annotated objects annotated to extrinsic apoptotic signaling pathway.
Link
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to extrinsic apoptotic signaling pathway.
Link
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