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extrinsic apoptotic signaling pathway via death domain receptors

Term Information

Accession
GO:0008625
Name
extrinsic apoptotic signaling pathway via death domain receptors
Ontology
biological_process
Synonyms
induction of apoptosis via death receptors, induction of apoptosis via death domain receptors, death receptor-mediated apoptosis
Alternate IDs
None
Definition
The series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with a ligand binding to a death domain receptor on the cell surface, and ends when the execution phase of apoptosis is triggered. Source: GOC:mah, GOC:mtg_apoptosis
Comment
Gene products that may be annotated to this term include: 1) ligands such as FASL; 2) receptors such as FAS/CD95 (though care should be taken because FAS can also act as a non-apoptotic signal transducer); 3) signaling molecules such as FADD (FAS-associated protein with a death domain), cIAPs (cellular inhibitor of apoptosis proteins), c-FLIPs and caspases 8 and 10. Examples are TWEAK (TNF12) and FN14 (TNFRSF12A) (UniProt symbols O43508 and Q9NP84) in PMID:21525013.
History
See term history for GO:0008625 at QuickGO
Subset
None
Feedback
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Parents of extrinsic apoptotic signaling pathway via death domain receptors (GO:0008625)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
extrinsic apoptotic signaling pathway via death domain receptors [is_a relation] is_a  extrinsic apoptotic signaling pathway (GO:0097191)
Children of extrinsic apoptotic signaling pathway via death domain receptors (GO:0008625)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043) [RO:0002213 relation] RO:0002213  extrinsic apoptotic signaling pathway via death domain receptors
regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902041) [RO:0002211 relation] RO:0002211  extrinsic apoptotic signaling pathway via death domain receptors
TRAIL-activated apoptotic signaling pathway (GO:0036462) [is_a relation] is_a  extrinsic apoptotic signaling pathway via death domain receptors
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902042) [RO:0002212 relation] RO:0002212  extrinsic apoptotic signaling pathway via death domain receptors
None.