You are using the Cyverse mirror of the Planteome Ontology Browser. The main site is currently down for maintenance.

Term Information

Accession
GO:0008625
Name
extrinsic apoptotic signaling pathway via death domain receptors
Ontology
biological_process
Synonyms
induction of apoptosis via death receptors, induction of apoptosis via death domain receptors, death receptor-mediated apoptosis
Alternate IDs
None
Definition
The series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with a ligand binding to a death domain receptor on the cell surface, and ends when the execution phase of apoptosis is triggered. Source: GOC:mah, GOC:mtg_apoptosis
Comment
Gene products that may be annotated to this term include: 1) ligands such as FASL; 2) receptors such as FAS/CD95 (though care should be taken because FAS can also act as a non-apoptotic signal transducer); 3) signaling molecules such as FADD (FAS-associated protein with a death domain), cIAPs (cellular inhibitor of apoptosis proteins), c-FLIPs and caspases 8 and 10. Examples are TWEAK (TNF12) and FN14 (TNFRSF12A) (UniProt symbols O43508 and Q9NP84) in PMID:21525013.
History
See term history for GO:0008625 at QuickGO
Subset
None
Feedback
Contact the Planteome feedback if you find mistakes or have concerns about the data you find here.
Comments, changes to terms, or requests for new ontology terms can be made at GO issue tracker on GitHub.

Filter results

Loading...
pending...
Parents of extrinsic apoptotic signaling pathway via death domain receptors (GO:0008625)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
extrinsic apoptotic signaling pathway via death domain receptors [is_a relation] is_a  extrinsic apoptotic signaling pathway (GO:0097191)
Children of extrinsic apoptotic signaling pathway via death domain receptors (GO:0008625)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043) [RO:0002213 relation] RO:0002213  extrinsic apoptotic signaling pathway via death domain receptors
regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902041) [RO:0002211 relation] RO:0002211  extrinsic apoptotic signaling pathway via death domain receptors
TRAIL-activated apoptotic signaling pathway (GO:0036462) [is_a relation] is_a  extrinsic apoptotic signaling pathway via death domain receptors
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902042) [RO:0002212 relation] RO:0002212  extrinsic apoptotic signaling pathway via death domain receptors
None.