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autophagic cell death

Term Information

Accession
GO:0048102
Name
autophagic cell death
Ontology
biological_process
Synonyms
programmed cell death by macroautophagy, autosis, type II programmed cell death, autophagic death, programmed cell death by autophagy
Alternate IDs
None
Definition
A form of programmed cell death that is accompanied by the formation of autophagosomes. Autophagic cell death is characterized by lack of chromatin condensation and massive vacuolization of the cytoplasm, with little or no uptake by phagocytic cells. Source: GOC:autophagy, GOC:mah, GOC:mtg_apoptosis, PMID:18846107, PMID:23347517
Comment
The precise nature of autophagic cell death is still being debated, and the link between autophagy and cell death unclear. As autophagy is often induced under conditions of stress that could also lead to cell death, there has been a propagation of the idea that autophagy can act as a cell death mechanism; but others suggest that autophagy may simply be an attempt of dying cells to adapt to lethal stress rather than a mechanism to execute a cell death program. Further studies are required to resolve this controversy (see e.g. PMID:22082964, PMID:22052193, PMID:25236395). In the meantime, curators should carefully examine the experimental evidence presented in papers concerning autophagic cell death, and annotate accordingly. Recently, an instance of autophagic cell death, termed autosis, was discovered that relies on the plasma membrane Na+/K+-ATPase. Autosis was observed in vivo in the brain of rats subjected to an ischemic insult. It's still unclear if all cases of autophagic cell death require the Na+/K+-ATPase or not.
History
See term history for GO:0048102 at QuickGO
Subset
None
Feedback
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Parents of autophagic cell death (GO:0048102)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
autophagic cell death [is_a relation] is_a  programmed cell death (GO:0012501)
autophagic cell death [BFO:0000051 relation] BFO:0000051  macroautophagy (GO:0016236)
Children of autophagic cell death (GO:0048102)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
negative regulation of autophagic cell death (GO:1904093) [RO:0002212 relation] RO:0002212  autophagic cell death
positive regulation of autophagic cell death (GO:1904094) [RO:0002213 relation] RO:0002213  autophagic cell death
salivary gland cell autophagic cell death (GO:0035071) [is_a relation] is_a  autophagic cell death
regulation of autophagic cell death (GO:1904092) [RO:0002211 relation] RO:0002211  autophagic cell death
None.