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macroautophagy

Term Information

Accession
GO:0016236
Name
macroautophagy
Ontology
biological_process
Synonyms
autophagy
Alternate IDs
GO:0034262
Definition
The major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane-bounded autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane-bounded structure. Autophagosomes then fuse with a lysosome (or vacuole) releasing single-membrane-bounded autophagic bodies that are then degraded within the lysosome (or vacuole). Some types of macroautophagy, e.g. pexophagy, mitophagy, involve selective targeting of the targets to be degraded. Source: PMID:11099404, PMID:12914914, PMID:16973210, PMID:15798367, PMID:9412464, PMID:20159618
Comment
Targeted macroautophagy sometimes targets regions of cytoplasm containing non-self, such as virus particles or components (e.g. see PMID:20159618). As this is essentially the same process as macroautophagy that encloses and digests only self, the term autophagy is still used despite the enclosure of some non-self (non-auto) entities.
History
See term history for GO:0016236 at QuickGO
Subset
None
Feedback
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Parents of macroautophagy (GO:0016236)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
macroautophagy [is_a relation] is_a  autophagy (GO:0006914)
Children of macroautophagy (GO:0016236)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
regulation of macroautophagy (GO:0016241) [RO:0002211 relation] RO:0002211  macroautophagy
autophagosome organization (GO:1905037) [BFO:0000050 relation] BFO:0000050  macroautophagy
autophagosome-endosome fusion (GO:0061910) [BFO:0000050 relation] BFO:0000050  macroautophagy
selective autophagy (GO:0061912) [is_a relation] is_a  macroautophagy
amphisome-lysosome fusion (GO:0061911) [BFO:0000050 relation] BFO:0000050  macroautophagy
autophagosome-lysosome fusion (GO:0061909) [BFO:0000050 relation] BFO:0000050  macroautophagy
autophagosome maturation (GO:0097352) [BFO:0000050 relation] BFO:0000050  macroautophagy
positive regulation of macroautophagy (GO:0016239) [RO:0002213 relation] RO:0002213  macroautophagy
autophagic cell death (GO:0048102) [BFO:0000051 relation] BFO:0000051  macroautophagy
negative regulation of macroautophagy (GO:0016242) [RO:0002212 relation] RO:0002212  macroautophagy
None.