Planteome: Term Details for "isotype switching" (GO:0045190)

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Term Information

Accession: GO:0045190
Name: isotype switching
Ontology: biological_process
Synonyms: class switch recombination, class switching, isotype switch recombination
Alternate IDs: None
Definition: The switching of activated B cells from IgM biosynthesis to biosynthesis of other isotypes of immunoglobulin, accomplished through a recombination process involving an intrachromosomal deletion involving switch regions that reside 5' of each constant region gene segment in the immunoglobulin heavy chain locus. Source: ISBN:0781735149
Comment: Note that IgM and IgD can be coexpressed by B cells via an alternate splicing mechanism, but true recombinational isotype switching to IgD has been demonstrated as well. Note that this term is best used to annotate gene products which are involved in the mechanism of DNA recombination used in isotype switching, like the B cell specific Swap70 factor in the mouse, rather than gene products which promote isotype switching such as cytokines or co-stimulatory molecules, which should instead be annotated to 'regulation of isotype switching ; GO:0045191'.
History: See term history for GO:0045190 at QuickGO
Subset: None
Related: Link to all annotated objects annotated to isotype switching.; Link to all direct and indirect annotations to isotype switching.; Link to all direct and indirect annotations download (limited to first 10,000) for isotype switching.
Feedback: Contact the Planteome feedback if you find mistakes or have concerns about the data you find here.
Comments, changes to terms, or requests for new ontology terms can be made at GO issue tracker on GitHub.

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BFO:0000001 entity
BFO:0000003 occurrent
BFO:0000015 process
GO:0008150 biological_process
GO:0009987 cellular process
GO:0008152 metabolic process
GO:0044237 cellular metabolic process
GO:0006807 nitrogen compound metabolic process
GO:0071704 organic substance metabolic process
GO:0006725 cellular aromatic compound metabolic process
GO:0034641 cellular nitrogen compound metabolic process
GO:0032502 developmental process
GO:0046483 heterocycle metabolic process
GO:0002376 immune system process
GO:1901360 organic cyclic compound metabolic process
GO:0044238 primary metabolic process
GO:0050896 response to stimulus
GO:0048856 anatomical structure development
GO:0002252 immune effector process
GO:0006955 immune response
GO:0043170 macromolecule metabolic process
GO:0032501 multicellular organismal process
GO:0006139 nucleobase-containing compound metabolic process
GO:0002250 adaptive immune response
GO:0002443 leukocyte mediated immunity
GO:0007275 multicellular organism development
GO:0090304 nucleic acid metabolic process
GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
GO:0006259 DNA metabolic process
GO:0010467 gene expression
GO:0002449 lymphocyte mediated immunity
GO:0048731 system development
GO:0019724 B cell mediated immunity
GO:0001775 cell activation
GO:0006310 DNA recombination
GO:0002520 immune system development
GO:0002440 production of molecular mediator of immune response
GO:0002263 cell activation involved in immune response
GO:0016064 immunoglobulin mediated immune response
GO:0002377 immunoglobulin production
GO:0045321 leukocyte activation
GO:0016444 somatic cell DNA recombination
GO:0002200 somatic diversification of immune receptors
GO:0002381 immunoglobulin production involved in immunoglobulin-mediated immune response
GO:0002366 leukocyte activation involved in immune response
GO:0046649 lymphocyte activation
GO:0002562 somatic diversification of immune receptors via germline recombination within a single locus
GO:0016445 somatic diversification of immunoglobulins
GO:0042113 B cell activation
GO:0002285 lymphocyte activation involved in immune response
GO:0002208 somatic diversification of immunoglobulins involved in immune response
GO:0016447 somatic recombination of immunoglobulin gene segments
GO:0002312 B cell activation involved in immune response
GO:0002204 somatic recombination of immunoglobulin genes involved in immune response
GO:0045190 isotype switching
GO:0048290 isotype switching to IgA isotypes
GO:0048292 isotype switching to IgD isotypes
GO:0048289 isotype switching to IgE isotypes
GO:0048291 isotype switching to IgG isotypes
GO:0045829 negative regulation of isotype switching
GO:0045830 positive regulation of isotype switching
GO:0045191 regulation of isotype switching

Parents of isotype switching (GO:0045190)

subject	relation	object
isotype switching	is_a	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)
isotype switching	is_a	B cell activation involved in immune response (GO:0002312)

Children of isotype switching (GO:0045190)

subject	relation	object
isotype switching to IgA isotypes (GO:0048290)	is_a	isotype switching
regulation of isotype switching (GO:0045191)	RO:0002211	isotype switching
isotype switching to IgE isotypes (GO:0048289)	is_a	isotype switching
negative regulation of isotype switching (GO:0045829)	RO:0002212	isotype switching
isotype switching to IgG isotypes (GO:0048291)	is_a	isotype switching
positive regulation of isotype switching (GO:0045830)	RO:0002213	isotype switching
isotype switching to IgD isotypes (GO:0048292)	is_a	isotype switching

Wikipedia: Immunoglobulin_class_switching