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ERAD pathway

Term Information

Accession
GO:0036503
Name
ERAD pathway
Ontology
biological_process
Synonyms
endoplasmic reticulum-associated degradation, protein degradation by ERAD, ER-associated degradation pathway, endoplasmic reticulum-associated protein degradation pathway
Alternate IDs
None
Definition
The protein catabolic pathway which targets endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. It begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein modifications necessary for correct substrate transfer (e.g. ubiquitination), transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome. Source: GOC:PARL, PMID:21969857, GOC:bf, PMID:20940304
Comment
ER-associated protein degradation (ERAD) pathways target misfolded ER lumenal proteins (ERAD-L), ER membrane proteins (ERAD-M), and ER proteins with misfolded cytosolic domains (ERAD-C) by recognizing aberrant proteins, retrotranslocating these substrates to the cytosol, followed by substrate ubiquitination and proteosomal-mediated degradation. In contrast the stress-induced homeostatically regulated protein degradation (SHRED) pathway (GO:0120174), although inducible by stress, targets diverse ER membrane, and cytosolic proteins as well as numerous other native proteins in the absence of stress. Stress results in the protease-mediated (Nma111p) generation of a Roq1p cleavage product that then binds to the type-1 active site of Ubr1p, altering its substrate specificity, and leading to the proteasome-mediated degradation of both misfolded and native proteins. Although the SHRED pathway may contain some components in common with ERAD pathways (GO:0036503), such as UBR1, RAD6 and CDC48, other ERAD components, such as HRD1 and DOA10, do not appear to be involved, and as such these pathways are currently considered to be distinct.
History
See term history for GO:0036503 at QuickGO
Subset
None
Feedback
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Parents of ERAD pathway (GO:0036503)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
ERAD pathway [is_a relation] is_a  response to organonitrogen compound (GO:0010243)
ERAD pathway [is_a relation] is_a  response to endoplasmic reticulum stress (GO:0034976)
ERAD pathway [is_a relation] is_a  proteasomal protein catabolic process (GO:0010498)
Children of ERAD pathway (GO:0036503)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
maintenance of unfolded protein involved in ERAD pathway (GO:1904378) [BFO:0000050 relation] BFO:0000050  ERAD pathway
retrograde protein transport, ER to cytosol (GO:0030970) [BFO:0000050 relation] BFO:0000050  ERAD pathway
regulation of ERAD pathway (GO:1904292) [RO:0002211 relation] RO:0002211  ERAD pathway
ER-associated misfolded protein catabolic process (GO:0071712) [is_a relation] is_a  ERAD pathway
protein localization to cytosolic proteasome complex involved in ERAD pathway (GO:1904379) [BFO:0000050 relation] BFO:0000050  ERAD pathway
ubiquitin-dependent ERAD pathway (GO:0030433) [is_a relation] is_a  ERAD pathway
positive regulation of ERAD pathway (GO:1904294) [RO:0002213 relation] RO:0002213  ERAD pathway
negative regulation of ERAD pathway (GO:1904293) [RO:0002212 relation] RO:0002212  ERAD pathway
None.