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Term Information

Accession
GO:0030433
Name
ubiquitin-dependent ERAD pathway
Ontology
biological_process
Synonyms
ER-associated ubiquitin-dependent protein breakdown, ER-associated ubiquitin-dependent protein catabolic process, ER-associated ubiquitin-dependent protein catabolism, ER-associated ubiquitin-dependent protein degradation, endoplasmic reticulum-associated ubiquitin-dependent protein catabolic process, endoplasmic reticulum-associated ubiqutin-dependent protein catabolism, ubiquitin-dependent proteasomal protein catabolism of ER proteins, ERAD
Alternate IDs
None
Definition
The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein ubiquitination necessary for correct substrate transfer, transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome. Source: PMID:14607247, GOC:rb, PMID:19520858, GOC:mah
Comment
See also the biological process terms 'ERAD pathway ; GO:0036503', 'unfolded protein response ; GO:0030968' and 'retrograde protein transport, ER to cytosol ; GO:0030970'.
History
See term history for GO:0030433 at QuickGO
Subset
None
Feedback
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Parents of ubiquitin-dependent ERAD pathway (GO:0030433)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
ubiquitin-dependent ERAD pathway [is_a relation] is_a  proteasome-mediated ubiquitin-dependent protein catabolic process (GO:0043161)
ubiquitin-dependent ERAD pathway [is_a relation] is_a  ERAD pathway (GO:0036503)
Children of ubiquitin-dependent ERAD pathway (GO:0030433)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
regulation of ER-associated ubiquitin-dependent protein catabolic process (GO:1903069) [RO:0002211 relation] RO:0002211  ubiquitin-dependent ERAD pathway
negative regulation of ER-associated ubiquitin-dependent protein catabolic process (GO:1903070) [RO:0002212 relation] RO:0002212  ubiquitin-dependent ERAD pathway
positive regulation of ER-associated ubiquitin-dependent protein catabolic process (GO:1903071) [RO:0002213 relation] RO:0002213  ubiquitin-dependent ERAD pathway
ubiquitin-dependent glycoprotein ERAD pathway (GO:0097466) [is_a relation] is_a  ubiquitin-dependent ERAD pathway
None.