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Term Information

Accession
GO:0006919
Name
activation of cysteine-type endopeptidase activity involved in apoptotic process
Ontology
biological_process
Synonyms
caspase activation, activation of caspase activity, activation of metacaspase activity
Alternate IDs
None
Definition
Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process. Source: GOC:al, GOC:dph, GOC:tb, PMID:18328827, GOC:jl, PMID:14744432, Wikipedia:Caspase, GOC:mtg_apoptosis
Comment
This term should be used when the annotation refers to a process that occurs in a context of apoptotic cell death. To annotate gene products involved in activation of cysteine-type endopeptidases in other cellular process (e.g., cell cycle arrest) that do not necessarily develop into an apoptotic process, please use the more general parent term GO:0097202. Examples of 'activation of cysteine-type endopeptidase activity involved in apoptotic process' are cytochrome c and Apaf1. When cytochrome c is released from mitochondria and forms a complex with Apaf1, they form a scaffolding platform in which the pro-caspase 9 is bound (the 'apoptosome'). The caspase is then cleaved and activated. Cytochrome c and Apaf1 are therefore involved in the conversion of the zymogen procaspase 9 to the active form of the caspase.
History
See term history for GO:0006919 at QuickGO
Subset
gocheck_do_not_annotate
Feedback
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Parents of activation of cysteine-type endopeptidase activity involved in apoptotic process (GO:0006919)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
activation of cysteine-type endopeptidase activity involved in apoptotic process [is_a relation] is_a  positive regulation of cysteine-type endopeptidase activity involved in apoptotic process (GO:0043280)
Children of activation of cysteine-type endopeptidase activity involved in apoptotic process (GO:0006919)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO:0008635) [is_a relation] is_a  activation of cysteine-type endopeptidase activity involved in apoptotic process
None.