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Term Information

Accession
GO:0004197
Name
cysteine-type endopeptidase activity
Ontology
molecular_function
Synonyms
thiol endopeptidase activity, caspase activity, lysosomal cysteine-type endopeptidase, metacaspase activity
Alternate IDs
None
Definition
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. Source: https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, GOC:mah
Comment
None
History
See term history for GO:0004197 at QuickGO
Subset
None
Feedback
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Comments, changes to terms, or requests for new ontology terms can be made at GO issue tracker on GitHub.

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Parents of cysteine-type endopeptidase activity (GO:0004197)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
cysteine-type endopeptidase activity [is_a relation] is_a  endopeptidase activity (GO:0004175)
cysteine-type endopeptidase activity [is_a relation] is_a  cysteine-type peptidase activity (GO:0008234)
Children of cysteine-type endopeptidase activity (GO:0004197)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
negative regulation of cysteine-type endopeptidase activity (GO:2000117) [RO:0002212 relation] RO:0002212  cysteine-type endopeptidase activity
calcium-dependent cysteine-type endopeptidase activity (GO:0004198) [is_a relation] is_a  cysteine-type endopeptidase activity
cysteine-type endopeptidase activity involved in apoptotic process (GO:0097153) [is_a relation] is_a  cysteine-type endopeptidase activity
GPI-anchor transamidase activity (GO:0003923) [is_a relation] is_a  cysteine-type endopeptidase activity
positive regulation of cysteine-type endopeptidase activity (GO:2001056) [RO:0002213 relation] RO:0002213  cysteine-type endopeptidase activity
regulation of cysteine-type endopeptidase activity (GO:2000116) [RO:0002211 relation] RO:0002211  cysteine-type endopeptidase activity
ubiquitin-like protein-specific endopeptidase activity (GO:0070137) [is_a relation] is_a  cysteine-type endopeptidase activity