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Term Information

Accession
GO:0000386
Name
second spliceosomal transesterification activity
Ontology
molecular_function
Synonyms
lariat formation, 5'-splice site cleavage, 3'-splice site cleavage, exon ligation
Alternate IDs
None
Definition
Catalysis of the second transesterification reaction of spliceosomal mRNA splicing. Ligation of the two exons occurs via a transesterification reaction where the free 3'-hydroxyl group of the 5' exon is the nucleophile attacking the 3' splice site. Non-expressed sequences are now detached from the exons. In cis splicing, the intron is in a lariat structure. Source: GOC:krc, PMID:19239890, ISBN:0879695897
Comment
None
History
See term history for GO:0000386 at QuickGO
Subset
None
Feedback
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Parents of second spliceosomal transesterification activity (GO:0000386)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
second spliceosomal transesterification activity [is_a relation] is_a  catalytic activity, acting on RNA (GO:0140098)
second spliceosomal transesterification activity [BFO:0000050 relation] BFO:0000050  RNA splicing, via transesterification reactions (GO:0000375)

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Reactome
R-HSA-9770236