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NPHP complex

Term Information

Accession
GO:1990957
Name
NPHP complex
Ontology
cellular_component
Synonyms
NPHP module
Alternate IDs
None
Definition
A protein complex that is located at the ciliary transition zone and consists of the NPHP4 and NPHP1 proteins. It acts as an organiser of the transition zone inner structure, specifically the Y-shaped links, in conjunction with the MKS complex. It is involved in ciliary protein trafficking and is required for correct functioning of the WNT and Hippo signaling pathways. Source: PMID:21422230, PMID:21555462, GOC:cilia, PMID:18337471, PMID:21498478, PMID:25150219
Comment
Although there is some evidence, it's still unclear if the MKS and NPHP complexes are constituent parts of the ciliary Y-shaped links or are simply responsible for aligning and attaching the Y-shaped links to the cilium membrane and axoneme.
History
See term history for GO:1990957 at QuickGO
Subset
None
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Parents of NPHP complex (GO:1990957)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
NPHP complex [is_a relation] is_a  protein-containing complex (GO:0032991)
NPHP complex [BFO:0000050 relation] BFO:0000050  ciliary transition zone (GO:0035869)

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None.