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titin-telethonin complex
Term Information
Accession
GO:1990733
Name
titin-telethonin complex
Ontology
cellular_component
Synonyms
Titin-Tcap complex
Alternate IDs
None
Definition
A protein complex formed between the N-terminus of the giant sarcomeric filament protein titin and the Z-disk ligand, telethonin. The complex is part of the Z-disk of the skeletal and cardiac sarcomere. Telethonin binding to titin might be essential for the initial assembly, stabilization and functional integrity of the titin filament, and hence important for muscle contraction relaxation in mature myofibrils.
Source:
GOC:ame,
PMID:16407954
Comment
An example of this are TTN and TCAP in human (UniProt symbols Q8WZ42 and O15273 respectively) in PMID:16407954 (inferred from direct assay).
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