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iNOS-S100A8/A9 complex

Term Information

Accession
GO:1990657
Name
iNOS-S100A8/A9 complex
Ontology
cellular_component
Synonyms
None
Alternate IDs
None
Definition
A protein complex capable of stimulus-inducible nitric-oxide synthase activity. S-nitrosylates cysteine residues in target proteins, a principal mechanism of nitric oxide (NO)-mediated signal transduction. In mammals consists of NOS2, S100A8 and S100A9. S100A9 acts both as an adaptor linking NOS2 to its target and as a transnitrosylase that transfers the nitric oxide moiety from NOS2 to its target, via its own S-nitrosylated cysteine. Source: PMID:25417112, GOC:bhm
Comment
An example of this is NOS2 in human (UniProt symbol P35228) in PMID:25417112 (inferred from direct assay).
History
See term history for GO:1990657 at QuickGO
Subset
None
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Parents of iNOS-S100A8/A9 complex (GO:1990657)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
iNOS-S100A8/A9 complex [is_a relation] is_a  transnitrosylase complex (GO:1990658)
iNOS-S100A8/A9 complex [is_a relation] is_a  nitric-oxide synthase complex (GO:1903958)

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None.