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ANPR-A receptor complex
Term Information
Accession
GO:1990620
Name
ANPR-A receptor complex
Ontology
cellular_component
Synonyms
NPR1 receptor complex
Alternate IDs
None
Definition
A receptor complex composed of two ANPR-A molecules and expressed in the heart atrium in mammals; it plays a major role in the regulation of blood pressure and salt-fluid volume homeostasis. Binding of the ligand AMP in response to atrial distension (high blood volume) leads to guanylate cyclase activity of the ANPR-A receptor complex, thereby elevating intracellular cGMP levels. The end result is a reduction in blood volume and, therefore, a reduction in cardiac output and systemic blood pressure.
Source:
GOC:ame,
PMID:15117952
Comment
An example of this is Npr1 in rat (UniProt symbol P18910) in PMID:15117952 (inferred from direct assay).
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