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HSP90-CDC37 chaperone complex

Term Information

Accession
GO:1990565
Name
HSP90-CDC37 chaperone complex
Ontology
cellular_component
Synonyms
None
Alternate IDs
None
Definition
A protein kinase chaperone complex required for the proper folding, maturation and stabilization of target proteins (mostly signalling protein kinases, some steroid hormone receptors), usually during or immediately after completion of translation. The highly conserved, phosphorylated CDC37-Ser13 (vertebrates) or cdc37-Ser14 (yeast) is essential for complex assembly and target protein binding. CDC37-Ser13 (Ser14) is phosphorylated by Casein kinase II (CK2), which in turn is a target of CDC37 creating a positive feedback loop. Complex binding also prevents rapid ubiquitin-dependent proteosomal degradation of target proteins. Source: PMID:22939624, GOC:PARL, PMID:21855797, GOC:pad, GOC:bhm
Comment
An example of this is HSP90AB1 in human (UniProt symbol P08238) in PMID:21855797 (inferred from direct assay).
History
See term history for GO:1990565 at QuickGO
Subset
None
Feedback
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Parents of HSP90-CDC37 chaperone complex (GO:1990565)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
HSP90-CDC37 chaperone complex [BFO:0000050 relation] BFO:0000050  cytoplasm (GO:0005737)
HSP90-CDC37 chaperone complex [is_a relation] is_a  protein folding chaperone complex (GO:0101031)

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None.