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Bfa1-Bub2 complex
Term Information
Accession
GO:1990334
Name
Bfa1-Bub2 complex
Ontology
cellular_component
Synonyms
None
Alternate IDs
None
Definition
A protein complex that acts as a two-component GTPase-activating protein for Tem1 GTPase, thus regulating a signal transduction cascade, called the mitotic exit network (MEN), which is required for mitotic exit and cytokinesis. Bub2/Bfa1 keeps Tem1 inactive until the spindle is properly oriented, thus inhibiting MEN activation.
Source:PMID:16449187,
GOC:bhm
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