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MUB1-RAD6-UBR2 ubiquitin ligase complex
Term Information
Accession
GO:1990304
Name
MUB1-RAD6-UBR2 ubiquitin ligase complex
Ontology
cellular_component
Synonyms
None
Alternate IDs
None
Definition
A ubiquitin ligase complex consisting of MUB1, RAD6 and UBR2 components. It ubiquitinates, and targets for destruction, the RPN4 transcription factor, which upregulates the proteasome genes. The binding of MUB1 may position the RPN4 ubiquitylation site proximal to the Ubiquitin-RAD6 thioester and allow the transfer of Ubiquitin from RAD6 to RPN4. One of its components, MUB1, is a short-lived protein ubiquitinated by the UBR2-RAD6 ubiquitin conjugating enzyme.
Source:PMID:18070918,
GOC:bhm
Comment
This complex has been identified in Saccharomyces cerevisiae (UniProt symbol P19812) - see PMID:18070918.
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