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STING complex
Term Information
Accession
GO:1990231
Name
STING complex
Ontology
cellular_component
Synonyms
stimulator of interferon genes complex
Alternate IDs
None
Definition
A protein dimer containing two STING monomers. It binds cyclic purine di-nucleotides. Activation of the sting complex by 2',5'-3'-5'-cyclic GMP-AMP activates nuclear transcription factor kB (NF-kB) and interferon regulatory factor 3 (IRF3) which then induce transcription of the genes encoding type I IFN and cytokines active in the innate immune response.
Source:PMID:23910378,
PMID:23706668,
PMID:22705373,
GOC:bhm
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