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Term Information

Accession
GO:1990195
Name
macrolide transmembrane transporter complex
Ontology
cellular_component
Synonyms
macrolide transporter, AcrAB-TolC complex, MacAB-TolC complex, macrolide transporter complex
Alternate IDs
None
Definition
A bacterial transmembrane transporter complex that spans the entire cell membrane system and possesses ATP-dependent xenobiotic transport activity pumping drugs (typically antibiotics) and other toxins directly from the cytosol out of the bacterial cell. Typically, it is trimeric consisting of a inner membrane ATPase (IMP), a periplasmic membrane fusion protein (MFP) and an outer membrane factor (OMF). In E. coli, macrolide transporter complexes may consists of MacB (IMP), MacA (MFP) and TolC (OMF) or AcrB (IMP), AcrA (MFP) and TolC (OMF). Trimeric TolC is a common OMF found in many macrolide transporter complexes. Source: PMID:10879525, PMID:18955484, PMID:19254725, GOC:bhm
Comment
None
History
See term history for GO:1990195 at QuickGO
Subset
None
Feedback
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Parents of macrolide transmembrane transporter complex (GO:1990195)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
macrolide transmembrane transporter complex [is_a relation] is_a  transmembrane transporter complex (GO:1902495)
Children of macrolide transmembrane transporter complex (GO:1990195)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
MacAB-TolC complex (GO:1990196) [is_a relation] is_a  macrolide transmembrane transporter complex
None.