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GATOR1 complex
Term Information
Accession
GO:1990130
Name
GATOR1 complex
Ontology
cellular_component
Synonyms
IML1 complex, SEACIT complex
Alternate IDs
None
Definition
A GTPase-activating protein (GAP) complex that regulates TORC1 signaling by interacting with the Rag GTPase. In human, the GATOR1 complex consists of DEPDC5, NPRL2, and NPRL3. In S. cerevisiae, this complex is referred to as SEACIT and contains the Iml1p, Npr2p, and Npr3p proteins.
Source:
GOC:krc,
PMID:21900499,
PMID:29199950,
GOC:rb,
PMID:23974112,
PMID:28199306,
PMID:23723238,
PMID:25934700
Comment
The Rag GTPase complex corresponds to Gtr1-Gtr2 GTPase complex ; GO:1990131.
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