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SeqA-DNA complex
Term Information
Accession
GO:1990097
Name
SeqA-DNA complex
Ontology
cellular_component
Synonyms
SeqA-dsDNA complex, SeqA-hemimethylated DNA complex, SeqA-hemimethylation dsDNA complex
Alternate IDs
None
Definition
A protein-DNA complex that contains an oligomer of SeqA bound to GATC sites in methylated or newly-synthesized, hemi-methylated double-stranded DNA, with preference for the latter. Binding of SeqA to hemimethylated DNA sequesters oriC, prevents re-methylation of DNA by Dam and in turn stops premature re-initiation of replication during one replication cycle.
Source:PMID:23149570,
PMID:15933720,
PMID:12379844,
GOC:bhm
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