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Term Information

Accession
GO:1904091
Name
non-ribosomal peptide synthetase activity
Ontology
molecular_function
Synonyms
peptidyl carrier protein activity involved in nonribosomal peptide biosynthesis, peptidyl carrier protein activity involved in nonribosomal peptide biosynthetic process, PCP, peptidyl carrier protein, peptidyl carrier protein activity
Alternate IDs
None
Definition
Catalysis of a multistep reaction that produce non-ribosomal peptides. The key chain-building reaction, a C-N bond-forming reaction, involves the generation of the characteristic peptide bond by nucleophilic attack of the amino group of an amino-acyl donor unit covalently bound to a downstream peptidyl carrier protein module (amino acyl-S-PCP) on the acyl group of an upstream electrophilic acyl- or peptidyl acyl-S-PCP chain, catalyzed by a condensation (C) domain. Supplementing these core chain-elongation domains are variable numbers of auxiliary domains that are responsible for modification of the growing polypeptide chain by a small set of iterated reactions including epimerization, N-methylation, and heterocyclization. Source: PMID:10631508, PMID:17502372
Comment
Examples are the ferrichrome synthetase Sib1 in S. pombe and the peptidyl carrier protein (PCP) module in bacterial nonribosomal peptide synthases (NRPSs), which holds the peptidyl group and acts as a swinging arm, limiting diffusion until the peptide comes into contact with the next enzymatic module in the NRPS process.
History
See term history for GO:1904091 at QuickGO
Subset
None
Feedback
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Parents of non-ribosomal peptide synthetase activity (GO:1904091)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
non-ribosomal peptide synthetase activity [is_a relation] is_a  catalytic activity (GO:0003824)
non-ribosomal peptide synthetase activity [BFO:0000050 relation] BFO:0000050  nonribosomal peptide biosynthetic process (GO:0019184)
Children of non-ribosomal peptide synthetase activity (GO:1904091)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
glutathione synthase activity (GO:0004363) [is_a relation] is_a  non-ribosomal peptide synthetase activity
amino acid ligation activity by nonribosomal peptide synthase (GO:0097429) [is_a relation] is_a  non-ribosomal peptide synthetase activity
None.