You are using the Cyverse mirror of the Planteome Ontology Browser. The main site is currently down for maintenance.

Term Information

Accession
GO:0140730
Name
amphiregulin production
Ontology
biological_process
Synonyms
AREG production
Alternate IDs
None
Definition
The appearance of amphiregulin due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Amphiregulin (AREG) is a ligand of the epidermal growth factor receptor (EGFR), a widely expressed transmembrane tyrosine kinase. AREG is synthesized as a membrane-anchored precursor protein that can engage in juxtacrine signaling on adjacent cells. Alternatively, after proteolytic processing by cell membrane proteases, mainly TACE/ADAM17, AREG is secreted and behaves as an autocrine or paracrine factor. Source: PMID:24463227
Comment
Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
History
See term history for GO:0140730 at QuickGO
Subset
gocheck_do_not_annotate
Feedback
Contact the Planteome feedback if you find mistakes or have concerns about the data you find here.
Comments, changes to terms, or requests for new ontology terms can be made at GO issue tracker on GitHub.

Filter results

Loading...
pending...
Parents of amphiregulin production (GO:0140730)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
amphiregulin production [is_a relation] is_a  cytokine production (GO:0001816)
Children of amphiregulin production (GO:0140730)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
regulation of amphiregulin production (GO:0140731) [RO:0002211 relation] RO:0002211  amphiregulin production
positive regulation of amphiregulin production (GO:0140732) [RO:0002213 relation] RO:0002213  amphiregulin production
None.