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Term Information

Accession
GO:0140624
Name
EGAD pathway
Ontology
biological_process
Synonyms
None
Alternate IDs
None
Definition
The protein catabolic pathway which selectively extracts ER-resident membrane proteins exported to the Golgi and endosomes for degradation by cytosolic proteasomes. It begins with phosphorylation of the ER-resident membrane protein, which triggers export of the protein from the ER to the Golgi and endosomes, followed by polyubiquitination by the Dsc E3 ubiquitin ligase complex and extraction of the ubiquitinated target, and ends with proteasomal degradation. Source: PMID:31368600
Comment
None
History
See term history for GO:0140624 at QuickGO
Subset
None
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Parents of EGAD pathway (GO:0140624)
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EGAD pathway [is_a relation] is_a  proteasomal protein catabolic process (GO:0010498)

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None.