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Term Information

Accession
GO:0140530
Name
MCM complex loading
Ontology
biological_process
Synonyms
MCM complex loading at replication origin, MCM double hexamer formation at replication origin
Alternate IDs
None
Definition
The protein localization process in which two MCM complexes become associated with chromatin at replication origins. MCM loading begins when origin-bound ORC and Cdc6 (Cdc18 in fission yeast) recruit one MCM2-7/Cdt1 complex to the origin, includes formation of a succession of intermediate complexes and ATP hydrolysis-dependent Mcm2-7 ring closure, and ends when two MCM hexamers fully encircle DNA, and are oriented head-to-head. The double hexamer is inactive for DNA unwinding. MCM loading takes place during G1 phase, and precedes CMG complex assembly. Source: PMID:28501329, PMID:23603117, PMID:28191893, PMID:28191894
Comment
None
History
See term history for GO:0140530 at QuickGO
Subset
None
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Parents of MCM complex loading (GO:0140530)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
MCM complex loading [is_a relation] is_a  protein-DNA complex assembly (GO:0065004)
MCM complex loading [is_a relation] is_a  cell cycle process (GO:0022402)
MCM complex loading [BFO:0000050 relation] BFO:0000050  nuclear cell cycle DNA replication initiation (GO:1902315)

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None.