Planteome: Term Details for "transcription regulator inhibitor activity" (GO:0140416)

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Term Information

Accession: GO:0140416
Name: transcription regulator inhibitor activity
Ontology: molecular_function
Synonyms: DNA-binding transcription factor inhibitor activity
Alternate IDs: None
Definition: A molecular function regulator that inhibits the activity of a transcription regulator via direct binding and/or post-translational modification. Source: PMID:10652346
Comment: Usage guidance: transcription regulator inhibitors bind to a transcription regulator to prevent it from reaching the chromatin. This activity does not occur at the promoter. For activities that do occur at the promoter, consider GO:0001217 ; DNA-binding transcription repressor activity or GO:0003714 ; transcription corepressor activity. An example of a transcription regulator is TCF23 Q7RTU1 is an example of a protein that regulates transcription factors by heterodimerising or binding to DbTFs and prevent DNA binding and their specific genomic binding site where the dbTF would have activated or repressed transcription. Also an example is NFKBIA P25963 which has a different way of regulating transcription factor activity by sequestering the dbTF (complex) in the cytoplasm. Another example is the HSP90 and HSP23 proteins that sequester steroid receptors away from the DNA.
History: See term history for GO:0140416 at QuickGO
Subset: None
Related: Link to all annotated objects annotated to transcription regulator inhibitor activity.; Link to all direct and indirect annotations to transcription regulator inhibitor activity.; Link to all direct and indirect annotations download (limited to first 10,000) for transcription regulator inhibitor activity.
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BFO:0000001 entity
BFO:0000003 occurrent
BFO:0000015 process
GO:0008150 biological_process
GO:0065007 biological regulation
GO:0008152 metabolic process
GO:0071704 organic substance metabolic process
GO:0050789 regulation of biological process
GO:0043170 macromolecule metabolic process
GO:0003674 molecular_function
GO:0019222 regulation of metabolic process
GO:0010467 gene expression
GO:0098772 molecular function regulator activity
GO:0060255 regulation of macromolecule metabolic process
GO:0140678 molecular function inhibitor activity
GO:0010468 regulation of gene expression
GO:0140416 transcription regulator inhibitor activity

Parents of transcription regulator inhibitor activity (GO:0140416)

subject	relation	object
transcription regulator inhibitor activity	is_a	molecular function inhibitor activity (GO:0140678)
transcription regulator inhibitor activity	BFO:0000050	regulation of gene expression (GO:0010468)

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transcription regulator inhibitor activity

Term Information

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Parents of transcription regulator inhibitor activity (GO:0140416)

None.