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Term Information

Accession
GO:0140328
Name
floppase activity
Ontology
molecular_function
Synonyms
floppase activity (cytosolic to exoplasmic leaftlet)
Alternate IDs
None
Definition
Catalysis of the movement of a lipid from the cytosolic to the exoplasmic leaftlet of a membrane, using energy from the hydrolysis of ATP. Source: PMID:20043909, PMID:25284293, Wikipedia:Flippase
Comment
Nomenclature note. Flippases and floppases are ATP-dependent transbilayer lipid translocators. According to an extensively used, though not universal, nomenclature, they catalyze lipid transfer towards the inward monolayer (flippases) or towards the outward monolayer (floppases). Scramblases are ATP-independent, non-selective, inducing non-specific transbilayer movements across the membrane. The direction of the translocation should be taken into account for annotation (from the cytosolic to the exoplasmic leaftlet of a membrane).
History
See term history for GO:0140328 at QuickGO
Subset
None
Feedback
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Parents of floppase activity (GO:0140328)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
floppase activity [is_a relation] is_a  ATPase-coupled intramembrane lipid transporter activity (GO:0140326)
Children of floppase activity (GO:0140328)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
phosphatidylcholine floppase activity (GO:0090554) [is_a relation] is_a  floppase activity
glycolipid floppase activity (GO:0034202) [is_a relation] is_a  floppase activity
sphingolipid floppase activity (GO:0046623) [is_a relation] is_a  floppase activity
lipopolysaccharide floppase activity (GO:0015437) [is_a relation] is_a  floppase activity
phosphatidylethanolamine floppase activity (GO:0140341) [is_a relation] is_a  floppase activity
lipid III floppase activity (GO:0015161) [is_a relation] is_a  floppase activity
phosphatidylserine floppase activity (GO:0090556) [is_a relation] is_a  floppase activity
None.