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Term Information

Accession
GO:0140078
Name
class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Ontology
molecular_function
Synonyms
AP site-DNA 5'-phosphomonoester-lyase activity, DNA-(apurinic or apyrimidinic site) 5'-phosphomonoester-lyase activity, DNA-(apurinic or apyrimidinic site) lyase activity, class I DNA-(apurinic or apyrimidinic site) lyase activity, AP endonuclease class I activity
Alternate IDs
None
Definition
Catalysis of the cleavage of an AP site 3' of the baseless site by a beta-lyase mechanism, leaving an unsaturated aldehyde, termed a 3'-(4-hydroxy-5-phospho-2-pentenal) residue, and a 5'-phosphate. Source: PMID:1698278, RHEA:66592
Comment
Note that this term is does not have parentage in the 'nuclease activity' branch of the ontology because both GO and the Enzyme Commission define nuclease activity as a type of hydrolysis. Class II AP endonuclease is a nuclease, but not Class I, III and IV.
History
See term history for GO:0140078 at QuickGO
Subset
None
Feedback
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Parents of class I DNA-(apurinic or apyrimidinic site) endonuclease activity (GO:0140078)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
class I DNA-(apurinic or apyrimidinic site) endonuclease activity [is_a relation] is_a  DNA-(apurinic or apyrimidinic site) endonuclease activity (GO:0003906)
class I DNA-(apurinic or apyrimidinic site) endonuclease activity [is_a relation] is_a  carbon-oxygen lyase activity (GO:0016835)

This term has no children.

EC
4.2.99.18
MetaCyc
4.2.99.18-RXN
RHEA
66592
Wikipedia
AP_endonuclease