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Term Information

Accession
GO:0120157
Name
PAR polarity complex
Ontology
cellular_component
Synonyms
apical polarity complex, BEM1-CDC24-CLA4 complex, Cdc42p GEF-PAK complex, PAR3-PAR6-atypical PKC, PAR3/PAR6/aPKC, PAR6-PAR3-aPKC complex
Alternate IDs
None
Definition
A protein kinase complex that is required for the establishment of a cell polarity axis during the cell division cycle. Binds directly to activated CDC42 GTPase and is required for orchestrating a cellular gradient of CDC42. In S. cerevisiae components are: BEM1, CDC24 and CLA4; from worms to vertebrates it contains a PAR6 protein, PAR3 protein and an atypical PKC. Source: PMID:18005931, PMID:28682236, GOC:lnp, PMID:11113154, PMID:22500799
Comment
"This tripartite complex named PAR6/PAR3/aPKC is conserved from worms to vertebrates" (PMID:18005931). In yeast, the components are BEM1, CDC24, and CLA4.
History
See term history for GO:0120157 at QuickGO
Subset
None
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Parents of PAR polarity complex (GO:0120157)
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PAR polarity complex [is_a relation] is_a  serine/threonine protein kinase complex (GO:1902554)

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