You are using the Cyverse mirror of the Planteome Ontology Browser. The main site is currently down for maintenance.

Term Information

Accession
GO:0106003
Name
amyloid-beta complex
Ontology
cellular_component
Synonyms
Abeta complex, amyloid beta complex, beta amyloid complex, beta-amyloid complex, betaA complex, A...
Alternate IDs
None
Definition
Protein complex involved in modulation of signaling and synaptic function in the brain, predominantly in the cerebral cortex and hippocampus. Forms dimers and multimers of amyloid beta peptide 40 and peptide 42 (proteolytic cleavage products of amyloid beta A4 protein, also known as amyloid beta precursor protein). Mostly found in the extracellular space with a proportion occurring as membrane-bound species. Influences synaptic plasticity through various receptors, mediates dendritic spine loss leading to decreased synapse density, inhibits long-term potentiation (LTP) and enhances long-term depression (LTD). Soluble multimeric form is the main pathogenic species linked to Alzheimer's disease. Source: PMID:18568035, GOC:bhm
Comment
An example is Protein 40 of APP (P05067-PRO_0000000093) in PMID:18568035 (inferred by direct assay).
History
See term history for GO:0106003 at QuickGO
Subset
None
Link to all annotated objects annotated to amyloid-beta complex.
Link to all direct and indirect annotations to amyloid-beta complex.
Link to all direct and indirect annotations download (limited to first 10,000) for amyloid-beta complex.
Feedback
Contact the Planteome feedback if you find mistakes or have concerns about the data you find here.
Comments, changes to terms, or requests for new ontology terms can be made at GO issue tracker on GitHub.
pending...
Parents of amyloid-beta complex (GO:0106003)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
amyloid-beta complex [is_a relation] is_a  protein-containing complex (GO:0032991)

This term has no children.

None.