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nucleolar exosome (RNase complex)
Term Information
Accession
GO:0101019
Name
nucleolar exosome (RNase complex)
Ontology
cellular_component
Synonyms
None
Alternate IDs
None
Definition
A ribonuclease complex that has 3-prime to 5-prime distributive hydrolytic exoribonuclease activity and in some taxa (e.g. yeast) endoribonuclease activity, producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured.
Source:PMID:26726035,
PMID:17174896,
PMID:20531386
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