Planteome logo
You are using the Cyverse mirror of the Planteome Ontology Browser. The main site is currently down for maintenance.

ferroptosis

Term Information

Accession
GO:0097707
Name
ferroptosis
Ontology
biological_process
Synonyms
iron-dependent programmed cell death
Alternate IDs
None
Definition
A programmed cell death characterized morphologically by the presence of smaller than normal mitochondria with condensed mitochondrial membrane densities, reduction or vanishing of mitochondria crista, and outer mitochondrial membrane rupture. Activation of mitochondrial voltage-dependent anion channels and mitogen-activated protein kinases, upregulation of endoplasmic reticulum stress, and inhibition of cystine/glutamate antiporter are involved in the induction of ferroptosis. This process is characterized by the accumulation of lipid peroxidation products and lethal reactive oxygen species (ROS) derived from iron metabolism. Glutathione peroxidase 4 (GPX4), heat shock protein beta-1, and nuclear factor erythroid 2-related factor 2 function as negative regulators of ferroptosis by limiting ROS production and reducing cellular iron uptake, respectively. In contrast, NADPH oxidase and p53 act as positive regulators of ferroptosis by promotion of ROS production and inhibition of expression of SLC7A11 (a specific light-chain subunit of the cystine/glutamate antiporter), respectively. Misregulated ferroptosis has been implicated in multiple physiological and pathological processes. Source: PMID:25236395, GOC:mtg_apoptosis, PMID:26794443
Comment
None
History
See term history for GO:0097707 at QuickGO
Subset
None
Feedback
Contact the Planteome feedback if you find mistakes or have concerns about the data you find here.
Comments, changes to terms, or requests for new ontology terms can be made at GO issue tracker on GitHub.

Filter results

Loading...
pending...
Parents of ferroptosis (GO:0097707)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
ferroptosis [is_a relation] is_a  programmed cell death (GO:0012501)
Children of ferroptosis (GO:0097707)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
positive regulation of ferroptosis (GO:0160020) [RO:0002213 relation] RO:0002213  ferroptosis
negative regulation of ferroptosis (GO:0110076) [RO:0002212 relation] RO:0002212  ferroptosis
regulation of ferroptosis (GO:0110075) [RO:0002211 relation] RO:0002211  ferroptosis
None.