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GAIT complex
Term Information
Accession
GO:0097452
Name
GAIT complex
Ontology
cellular_component
Synonyms
IFN-gamma-activated inhibitor of translation complex, gamma interferon-activated inhibitor of translation complex
Alternate IDs
None
Definition
A protein complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. The complex binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs and suppresses their translation by blocking the recruitment of the 43S ribosomal complex to m7G cap-bound eIF4G. In humans it includes RPL13A, EPRS, SYNCRIP and GAPDH; mouse complexes lack SYNCRIP.
Source:PMID:15479637,
GOC:br,
PMID:23071094
Link
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Link
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Link
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