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hypoxia-inducible factor-1alpha signaling pathway

Term Information

Accession
GO:0097411
Name
hypoxia-inducible factor-1alpha signaling pathway
Ontology
biological_process
Synonyms
HIF1alpha pathway, hypoxia-inducible factor signaling, hypoxia-inducible factor-1alpha signalling pathway
Alternate IDs
None
Definition
The series of molecular signals mediated by hypoxia-inducible factor (HIF1) in response to lowered oxygen levels (hypoxia). Under hypoxic conditions, the oxygen-sensitive alpha-subunit of hypoxia-inducible factor (HIF)-1 dimerizes with a HIF1-beta subunit (also called ARNT or aryl-hydrocarbon-receptor nuclear translocator), translocates to the nucleus and activates transcription of genes whose products participate in responding to hypoxia. Source: GOC:bf, http://www.sabiosciences.com/pathway.php?sn=HIF1Alpha_Pathway, GOC:jc
Comment
None
History
See term history for GO:0097411 at QuickGO
Subset
None
Feedback
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Parents of hypoxia-inducible factor-1alpha signaling pathway (GO:0097411)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
hypoxia-inducible factor-1alpha signaling pathway [BFO:0000050 relation] BFO:0000050  cellular response to hypoxia (GO:0071456)
hypoxia-inducible factor-1alpha signaling pathway [is_a relation] is_a  signal transduction (GO:0007165)
Children of hypoxia-inducible factor-1alpha signaling pathway (GO:0097411)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
negative regulation of hypoxia-inducible factor-1alpha signaling pathway (GO:1902072) [RO:0002212 relation] RO:0002212  hypoxia-inducible factor-1alpha signaling pathway
positive regulation of hypoxia-inducible factor-1alpha signaling pathway (GO:1902073) [RO:0002213 relation] RO:0002213  hypoxia-inducible factor-1alpha signaling pathway
regulation of hypoxia-inducible factor-1alpha signaling pathway (GO:1902071) [RO:0002211 relation] RO:0002211  hypoxia-inducible factor-1alpha signaling pathway
None.