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ripoptosome

Term Information

Accession
GO:0097342
Name
ripoptosome
Ontology
cellular_component
Synonyms
necrosome, TNFR1 complex II, Tnfr1-CII
Alternate IDs
None
Definition
A protein complex whose core components are the receptor-interacting serine/threonine-protein kinases RIPK1 and RIPK3 (also called RIP1 and RIP3). Formation of the ripoptosome can induce an extrinsic apoptotic signaling pathway or a necroptotic signaling pathway. The composition of this protein complex may depend on several factors including nature of the signal, cell type and more. Source: GOC:mtg_apoptosis, PMID:22274400, GOC:bhm, PMID:22265414
Comment
It has been shown that receptor-mediated necroptotic signaling pathway requires assembly of a ripoptosome protein complex consisting of caspase-8, caspase-10, Fas-associated death domain protein (FADD), casp8 and FADD-like apoptosis regulator (CFLAR) as well as the two receptor-interacting serine/threonine-protein kinases RIPK1 and RIPK3 (PMID:21737330). Optionally, depending on the receptor activated, this complex may contain TLR3 adaptor protein TRIF (PMID:21737330).
History
See term history for GO:0097342 at QuickGO
Subset
None
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Parents of ripoptosome (GO:0097342)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
ripoptosome [is_a relation] is_a  catalytic complex (GO:1902494)
ripoptosome [BFO:0000050 relation] BFO:0000050  cytosol (GO:0005829)

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None.