You are using the Cyverse mirror of the Planteome Ontology Browser. The main site is currently down for maintenance.

Term Information

Accession
GO:0086102
Name
adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate
Ontology
biological_process
Synonyms
G-protein coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate via inhibition of adenylate cyclase activity, adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate, muscarinic receptor signalling pathway involved in negative regulation of heart rate by inhibition of If channel, muscarinic receptor signalling pathway involved in negative regulation of heart rate by inhibition of funny current, AC-inhibiting muscarinic receptor signaling pathway involved in negative regulation of heart rate, Gi-coupled G-protein coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate
Alternate IDs
None
Definition
An adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway that contributes to a decrease in frequency or rate of heart contraction through inhibition of adenylate cyclase (AC) activity. Binding of acetylcholine to a G protein-coupled (muscarinic) receptor on the surface of the signal-receiving cell results in the activation of an intracellular Gi/o protein. Gi/o inhibits adenylate cyclase to decrease cyclic-AMP (cAMP) levels. Since cAMP binds directly to F-channels to allow an inward flow of sodium (funny current, If current), a reduction in cAMP reduces the funny current to bring about membrane hyperpolarization and a decrease in heart rate. Source: GOC:BHF, GOC:mtg_cardiac_conduct_nov11
Comment
None
History
See term history for GO:0086102 at QuickGO
Subset
None
Feedback
Contact the Planteome feedback if you find mistakes or have concerns about the data you find here.
Comments, changes to terms, or requests for new ontology terms can be made at GO issue tracker on GitHub.

Filter results

Loading...
pending...
Parents of adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate (GO:0086102)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate [is_a relation] is_a  adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway (GO:0007197)
adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate [is_a relation] is_a  G protein-coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate (GO:0086033)
adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate [BFO:0000050 relation] BFO:0000050  negative regulation of heart rate (GO:0010459)

This term has no children.

None.