Planteome: Term Details for "gene silencing by RNA-directed DNA methylation" (GO:0080188)

Term Information

Accession: GO:0080188
Name: gene silencing by RNA-directed DNA methylation
Ontology: biological_process
Synonyms: RdDM, RNA-directed DNA methylation
Alternate IDs: None
Definition: A small RNA-based gene silencing process in which small interfering RNAs (siRNAs) guide DNA methylation to the siRNA-generating genomic loci and other loci that are homologous to the siRNAs for de novo DNA methylation. This results in a heterochromatin assembly, a chromatin conformation that is refractory to transcription. In general this process consists of three phases: biogenesis of siRNAs, scaffold RNA production, and the formation of the guiding complex that recruits de novo DNA methyltransferases to the target loci. Transposable elements are silenced by this mechanism. Source: PMID:21420348
Comment: This process has been shown in plants and in yeasts, but so far has not been detected in vertebrates, organisms that lack RNA-dependent RNA polymerase.
History: See term history for GO:0080188 at QuickGO
Subset: None
Related: Link to all annotated objects annotated to gene silencing by RNA-directed DNA methylation.; Link to all direct and indirect annotations to gene silencing by RNA-directed DNA methylation.; Link to all direct and indirect annotations download (limited to first 10,000) for gene silencing by RNA-directed DNA methylation.
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Comments, changes to terms, or requests for new ontology terms can be made at GO issue tracker on GitHub.

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BFO:0000001 entity
BFO:0000003 occurrent
BFO:0000015 process
GO:0008150 biological_process
GO:0009987 cellular process
GO:0071840 cellular component organization or biogenesis
GO:0065007 biological regulation
GO:0016043 cellular component organization
GO:0008152 metabolic process
GO:0071704 organic substance metabolic process
GO:0043933 protein-containing complex organization
GO:0050789 regulation of biological process
GO:0043170 macromolecule metabolic process
GO:0048519 negative regulation of biological process
GO:0071824 protein-DNA complex organization
GO:0019222 regulation of metabolic process
GO:0006325 chromatin organization
GO:0010467 gene expression
GO:0009892 negative regulation of metabolic process
GO:0060255 regulation of macromolecule metabolic process
GO:0006338 chromatin remodeling
GO:0010605 negative regulation of macromolecule metabolic process
GO:0010468 regulation of gene expression
GO:0040029 epigenetic regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0070828 heterochromatin organization
GO:0045814 negative regulation of gene expression, epigenetic
GO:0031507 heterochromatin formation
GO:0140718 facultative heterochromatin formation
GO:0031047 regulatory ncRNA-mediated gene silencing
GO:0006346 DNA methylation-dependent heterochromatin formation
GO:0031048 regulatory ncRNA-mediated heterochromatin formation
GO:0080188 gene silencing by RNA-directed DNA methylation
GO:0141010 retrotransposon silencing by RNA-directed DNA methylation

Parents of gene silencing by RNA-directed DNA methylation (GO:0080188)

subject	relation	object
gene silencing by RNA-directed DNA methylation	is_a	regulatory ncRNA-mediated heterochromatin formation (GO:0031048)
gene silencing by RNA-directed DNA methylation	is_a	DNA methylation-dependent heterochromatin formation (GO:0006346)

Children of gene silencing by RNA-directed DNA methylation (GO:0080188)

subject	relation	object
retrotransposon silencing by RNA-directed DNA methylation (GO:0141010)	is_a	gene silencing by RNA-directed DNA methylation

gene silencing by RNA-directed DNA methylation

Term Information

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Parents of gene silencing by RNA-directed DNA methylation (GO:0080188)

Children of gene silencing by RNA-directed DNA methylation (GO:0080188)

None.