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box H/ACA RNP complex

Term Information

Accession
GO:0072588
Name
box H/ACA RNP complex
Ontology
cellular_component
Synonyms
box H/ACA snoRNP pseudouridylase complex, sRNP complex
Alternate IDs
None
Definition
A ribonucleoprotein complex that contains an RNA of the box H/ACA type and the four core proteins dyskerin, NOP10, NHP2, and GAR1 (human protein nomenclature). RNA pseudouridylation (isomerization of uridine to pseudouridine) is the major, and most likely the ancestral, function of H/ACA RNPs. Pseudouridylation targets include both large and small ribosomal RNAs (rRNAs), and small nuclear RNA (U2 snRNA). In addition to these catalytic H/ACA RNPs, a less abundant but more diverse class of structural H/ACA RNPs exists, which does not have pseudouridylation activity. These include the vertebrate telomerase RNP complex. Source: GOC:BHF_telomerase, PMID:20227365, GOC:krc, PMID:17284456, GOC:jbu, GOC:BHF, GOC:vw, GOC:mah
Comment
None
History
See term history for GO:0072588 at QuickGO
Subset
None
Feedback
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Parents of box H/ACA RNP complex (GO:0072588)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
box H/ACA RNP complex [is_a relation] is_a  sno(s)RNA-containing ribonucleoprotein complex (GO:0005732)
Children of box H/ACA RNP complex (GO:0072588)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
box H/ACA scaRNP complex (GO:0072589) [is_a relation] is_a  box H/ACA RNP complex
box H/ACA telomerase RNP complex (GO:0090661) [is_a relation] is_a  box H/ACA RNP complex
box H/ACA snoRNP complex (GO:0031429) [is_a relation] is_a  box H/ACA RNP complex
None.