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Term Information

Accession
GO:0072580
Name
bacterial-type EF-P lysine modification
Ontology
biological_process
Synonyms
EF-P modification pathway
Alternate IDs
None
Definition
The modification of a lysine residue in a protein to produce (2S)-2-amino-6-([(3S)-3,6-diaminohexanoyl]amino)hexanoic acid, and the subsequent hydroxylation of the modified lysine residue. This modification is observed in, and is probably unique to, the prokaryotic translation elongation factor P (EF-P). Source: GOC:curators, RESID:AA0530, RESID:AA0531, GOC:mah, PMID:20729861, PMID:22706199, GOC:imk
Comment
The EF-P modification pathway is now thought to be composed of three steps: conversion of alpha-lysyl-EF-P to beta-lysyl-EF-P, lysylation of Lys34, and hydroxylation of Lys34.
History
See term history for GO:0072580 at QuickGO
Subset
gocheck_do_not_annotate
Feedback
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Parents of bacterial-type EF-P lysine modification (GO:0072580)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
bacterial-type EF-P lysine modification [is_a relation] is_a  peptidyl-lysine modification (GO:0018205)
Children of bacterial-type EF-P lysine modification (GO:0072580)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
peptidyl-lysine hydroxylation involved in bacterial-type EF-P lysine modification (GO:1901260) [BFO:0000050 relation] BFO:0000050  bacterial-type EF-P lysine modification
protein-N6-(L-lysyl)-L-lysine modification to protein-N6-(beta-lysyl)-L-lysine (GO:0072581) [BFO:0000050 relation] BFO:0000050  bacterial-type EF-P lysine modification
protein-lysine lysylation (GO:0071915) [BFO:0000050 relation] BFO:0000050  bacterial-type EF-P lysine modification
None.