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NF-kappaB complex
Term Information
Accession
GO:0071159
Name
NF-kappaB complex
Ontology
cellular_component
Synonyms
None
Alternate IDs
None
Definition
A protein complex that consists of a homo- or heterodimer of members of a family of structurally related proteins that contain a conserved N-terminal region called the Rel homology domain (RHD). In the nucleus, NF-kappaB complexes act as transcription factors. In unstimulated cells, NF-kappaB dimers are sequestered in the cytoplasm by IkappaB monomers; signals that induce NF-kappaB activity cause degradation of IkappaB, allowing NF-kappaB dimers to translocate to the nucleus and induce gene expression.
Source:ISBN:0849327946
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