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error-free translesion synthesis
Term Information
Accession
GO:0070987
Name
error-free translesion synthesis
Ontology
biological_process
Synonyms
None
Alternate IDs
None
Definition
The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication by using a specialized DNA polymerase or replication complex to insert a defined nucleotide across the lesion. This process does not remove the replication-blocking lesions but does not causes an increase in the endogenous mutation level. For S. cerevisiae, RAD30 encodes DNA polymerase eta, which incorporates two adenines. When incorporated across a thymine-thymine dimer, it does not increase the endogenous mutation level.
Source:
GOC:elh
Comment
Note that 'error-free' does not mean that literally zero errors occur during DNA synthesis, but that the error rate is low, comparable to that of DNA synthesis during replication.
Link
to all annotated objects annotated to error-free translesion synthesis.
Link
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to error-free translesion synthesis.
Link
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for error-free translesion synthesis.
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