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Term Information

Accession
GO:0070922
Name
RISC complex assembly
Ontology
biological_process
Synonyms
RISC assembly, gene silencing by RNA, small RNA loading onto RISC, small RNA loading onto RISC, miRNA loading onto RISC, siRNA loading onto RISC involved in RNA interference, siRNA loading onto RISC involved in gene silencing by small RNA, miRISC assembly
Alternate IDs
GO:0035280, GO:0070923, GO:0035087
Definition
The process in which a single-stranded small RNA is incorporated within the RNA-initiated silencing complex (RISC). The assembly includes the maturation of the small RNA, the stabilization of the complex by accessory proteins of the RISC complex, duplex separation and the release of the second strand, forming a base-pairing completent complex that mediates gene silencing by small RNA. Source: PMID:27184117, PMID:14512631, PMID:14744438, PMID:22233755, PMID:19239886
Comment
None
History
See term history for GO:0070922 at QuickGO
Subset
None
Feedback
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Parents of RISC complex assembly (GO:0070922)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
RISC complex assembly [is_a relation] is_a  protein-RNA complex assembly (GO:0022618)
RISC complex assembly [BFO:0000050 relation] BFO:0000050  regulatory ncRNA-mediated gene silencing (GO:0031047)

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