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core mediator complex

Term Information

Accession
GO:0070847
Name
core mediator complex
Ontology
cellular_component
Synonyms
C mediator complex, S mediator complex
Alternate IDs
None
Definition
A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The core mediator complex has a stimulatory effect on basal transcription, and contains most of the same subdomains as the larger form of mediator complex -- a head domain comprising proteins known in Saccharomyces as Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; and a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p -- but lacks the regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan core mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins. Source: PMID:16168358, PMID:11454195, PMID:17870225
Comment
None
History
See term history for GO:0070847 at QuickGO
Subset
None
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Parents of core mediator complex (GO:0070847)
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core mediator complex [is_a relation] is_a  RNA polymerase II transcription regulator complex (GO:0090575)

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