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gamma-secretase complex

Term Information

Accession
GO:0070765
Name
gamma-secretase complex
Ontology
cellular_component
Synonyms
presenilin complex, CD147-gamma-secretase complex (APH-1a, PS-1, PEN-2, NCT variant), PS1 complex, PS2 complex, gamma-secretase complex (APH1A, PSEN1, PSENEN, NCSTN variant), gamma-secretase complex (APH1A, PSEN2, PSENEN, NCSTN), gamma-secretase complex (APH1B, PSEN1, PSENEN, NCSTN), gamma-secretase complex (APH1B, PSEN2, PSENEN, NCSTN)
Alternate IDs
None
Definition
A protein complex that has aspartic-type endopeptidase activity and contains a presenilin catalytic subunit (either PSEN1 or PSEN2), an APH1 subunit (multiple genes and splice variants exist), nicastrin (NCT), and presenilin enhancer (aka PEN-2 or Psenen), as the core complex. Variants of the complex with different subunit compositions differ in localization and specific substrates. Additionally, variants of the complex exist that contain a additional regulatory subunit as well as the four core subunits; known regulatory subunits include gamma-secretase-activating protein (aka gSAP), TMP1 (aka TMED10), and CD147 antigen (aka basigin). Gamma-secretase cleaves type I transmembrane protein substrates, including the cell surface receptor Notch and the amyloid-beta precursor protein. Source: PMID:17047368, GOC:krc, PMID:22122073, PMID:15890777, PMID:32616437, PMID:15286082, PMID:25565961, PMID:28320827
Comment
None
History
See term history for GO:0070765 at QuickGO
Subset
None
Feedback
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Parents of gamma-secretase complex (GO:0070765)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
gamma-secretase complex [is_a relation] is_a  catalytic complex (GO:1902494)
gamma-secretase complex [is_a relation] is_a  plasma membrane protein complex (GO:0098797)

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None.