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base J metabolic process
Term Information
Accession
GO:0070580
Name
base J metabolic process
Ontology
biological_process
Synonyms
base J metabolism, beta-D-glucosyl-HOMedU metabolic process, beta-D-glucosyl-hydroxymethyluracil metabolism
Alternate IDs
None
Definition
The chemical reactions and pathways involving base J (beta-D-glucosyl-hydroxymethyluracil), a hypermodified thymidine residue found in the genome of kinetoplastid parasites. This modified base is localized primarily to repetitive DNA, namely the telomeres, and is implicated in the regulation of antigenic variation. The base is synthesized in a two-step pathway. Initially, a thymidine residue in DNA is hydroxylated by a thymidine hydroxylase (TH) to form the intermediate hydroxymethyluracil, which is then glucosylated to form base J.
Source:PMID:19114062
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