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Term Information

Accession
GO:0070580
Name
base J metabolic process
Ontology
biological_process
Synonyms
base J metabolism, beta-D-glucosyl-HOMedU metabolic process, beta-D-glucosyl-hydroxymethyluracil metabolism
Alternate IDs
None
Definition
The chemical reactions and pathways involving base J (beta-D-glucosyl-hydroxymethyluracil), a hypermodified thymidine residue found in the genome of kinetoplastid parasites. This modified base is localized primarily to repetitive DNA, namely the telomeres, and is implicated in the regulation of antigenic variation. The base is synthesized in a two-step pathway. Initially, a thymidine residue in DNA is hydroxylated by a thymidine hydroxylase (TH) to form the intermediate hydroxymethyluracil, which is then glucosylated to form base J. Source: PMID:19114062
Comment
None
History
See term history for GO:0070580 at QuickGO
Subset
None
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Parents of base J metabolic process (GO:0070580)
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base J metabolic process [is_a relation] is_a  DNA modification (GO:0006304)

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