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Term Information

Accession
GO:0070578
Name
RISC-loading complex
Ontology
cellular_component
Synonyms
miRLC, microRNA loading complex, RLC
Alternate IDs
None
Definition
A trimeric protein complex required for the formation of a mature RNA-induced silencing complex (RISC). In humans the complex is composed of the endonuclease Dicer (DICER1), TRBP (TARBP2) and the Argonaute protein Ago2 (EIF2C2/AGO2). Within the complex, Dicer and TRBP are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto Ago2. Ago2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from Dicer and TRBP. This complex has endoribonuclease activity. Source: GOC:rph, PMID:19820710, GOC:BHF, GOC:ab, PMID:18178619, GOC:nc
Comment
None
History
See term history for GO:0070578 at QuickGO
Subset
None
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Parents of RISC-loading complex (GO:0070578)
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RISC-loading complex [is_a relation] is_a  endoribonuclease complex (GO:1902555)

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