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Term Information

Accession
GO:0060395
Name
SMAD protein signal transduction
Ontology
biological_process
Synonyms
None
Alternate IDs
None
Definition
An intracellular signal transduction pathway that starts with the activation of a SMAD protein, leading to the formation of a complex with co-SMADs, which translocates to the nucleus, where it regulates transcription of specific target genes. Source: GOC:BHF
Comment
Note that the upstream receptor and its ligand regulate the pathway (and are not part of the SMAD pathway), since it is an intracellular signaling pathway.
History
See term history for GO:0060395 at QuickGO
Subset
None
Feedback
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Parents of SMAD protein signal transduction (GO:0060395)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
SMAD protein signal transduction [is_a relation] is_a  intracellular signal transduction (GO:0035556)
SMAD protein signal transduction [BFO:0000050 relation] BFO:0000050  transmembrane receptor protein serine/threonine kinase signaling pathway (GO:0007178)
Children of SMAD protein signal transduction (GO:0060395)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
negative regulation of SMAD protein signal transduction (GO:0060392) [RO:0002212 relation] RO:0002212  SMAD protein signal transduction
positive regulation of SMAD protein signal transduction (GO:0060391) [RO:0002213 relation] RO:0002213  SMAD protein signal transduction
regulation of SMAD protein signal transduction (GO:0060390) [RO:0002211 relation] RO:0002211  SMAD protein signal transduction
None.