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lysine biosynthetic process via alpha-aminoadipate and N2-acetyl-alpha-aminoadipate
Term Information
Accession
GO:0051976
Name
lysine biosynthetic process via alpha-aminoadipate and N2-acetyl-alpha-aminoadipate
Ontology
biological_process
Synonyms
lysine biosynthesis via aminoadipic acid and N2-acetyl-alpha-aminoadipate, lysine biosynthetic process via aminoadipic acid and N2-acetyl-alpha-aminoadipate
Alternate IDs
None
Definition
The chemical reactions and pathways resulting in the formation of lysine via the intermediates alpha-aminoadipic acid and N2-acetyl-alpha-aminoadipate. This pathway of prokaryotic lysine biosynthesis via alpha-aminoadipate was discovered in the hyper-thermophilic Gram-negative eubacterium Thermus thermophilus. The pathway proceeds as follows: alpha-ketoglutarate is converted to homocitrate, which is metabolized to 3-carboxyhex-2-enedioate and then homoisocitrate. This is then decarboxylated to form alpha-ketoadipate, which is then converted to alpha-aminoadipate. This undergoes acetylation, to form N2-acetyl-alpha-aminoadipate, and is then phosphorylated to give N2-acetyl-alpha-aminoadipyl-delta-phosphate. This is converted to N2-acetyl-alpha-aminoadipate semialdehyde, which is then converted to N2-acetyl-L-lysine. A final deacetylation reaction produces L-lysine.
Source:MetaCyc:PWY-3081
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